Figure 2.

(a) Schematic of pressurized reaction module (PRM). The reaction vessel is contained within a heating/cooling jacket that controls its temperature. Pneumatic actuators acting in the vertical direction and a stepper motor in the horizontal direction allow the vessel to be positioned at different fluidic interfaces (labeled “1”, “2” and “3”). A flat gasket material provides a gas-tight seal at each interface. Station “1” provides one or more lines for incoming reagents as well as a nitrogen stream and vacuum to facilitate evaporations. Though only one reagent line is shown, typically two are used: one for [¹⁸F]fluoride or product of previous step, and one for reagents that must be added to complete the current step. Station “2” provides a seal only and is for pressurized reactions. Station “3” provides nitrogen supply and a dip tube for transferring reagents out of the vessel into the next reaction or purification module. (b) Corresponding photograph of the PRM. The insets at top show details of the fluidic interfaces and gaskets.