Sir2, Sir3, and Sir4 enrichment at all 32 yeast telomeres. ChIP-Seq of Myc-tagged Sir2, Sir3, and Sir4 was analyzed at all yeast telomeres. (Left) The first 20 kbp of each chromosome. (Right) The last 20 kbp of each chromosome. IP/input enrichment values for Sir2 (green), Sir3 (blue), and Sir4 (green) are shown for each telomere. On chromosome III, HML is boxed in red, and regions absent in the sequenced W303 strain relative to the S288C sacCer2 genome are represented by a gray-shaded box.