Table 1. Subtelomeric genes under Sir2/3/4 repression.
| Gene | Systematic name | Wild type | sir2Δ | sir3Δ | sir4Δ | Distance to nearest sir peak (bp) |
|---|---|---|---|---|---|---|
| IMD1 | YAR073W | 0.1 | 1.1 | 1.1 | 1.1 | 1,575 |
| YAR075W | YAR075W | 1.6 | 26 | 21.9 | 25 | 846 |
| YCL076W | YCL076W | 0 | 3.3 | 2.8 | 3.5 | 0 |
| YCL075W | YCL075W | 0 | 1.9 | 2.6 | 2.8 | 0 |
| YCL074W | YCL074W | 0 | 4.5 | 6.5 | 4.9 | 0 |
| GEX1 | YCL073C | 0.1 | 0.4 | 0.5 | 0.5 | 0 |
| VBA3 | YCL069W | 0.4 | 3.5 | 3.9 | 4.5 | 0 |
| YCL068C | YCL068C | 0.1 | 4.8 | 0.5 | 7.4 | 0 |
| YCL065W | YCL065W | 0 | 14.9 | 9.1 | 9.2 | 0 |
| CHA1 | YCL064C | 51.2 | 148 | 229.4 | 242.2 | 0 |
| YFL063W | YFL063W | 0 | 1.7 | 1.2 | 0.4 | 175 |
| COS4 | YFL062W | 5 | 12.5 | 15.3 | 18.1 | 1,527 |
| THI5 | YFL058W | 1.3 | 4.4 | 3.8 | 3.1 | 7,972 |
| YFR057W | YFR057W | 0.2 | 12 | 9.7 | 10.8 | 529 |
| YPS5 | YGL259W | 0.2 | 2.9 | 3.3 | 2.7 | 2,836 |
| YGL258W-A | YGL258W-A | 3.4 | 13.1 | 27.8 | 29.7 | 3,396 |
| IMD2 | YHR216W | 61.5 | 234.2 | 331.9 | 352.5 | 989 |
| PAU4 | YLR461W | 0.5 | 1.1 | 1.6 | 1.9 | 1,239 |
| YNL337W | YNL337W | 0 | 2.2 | 0.4 | 0.6 | 77 |
| AAD15 | YOL165C | 2.1 | 7.2 | 10.1 | 10.4 | 0 |
| FDH1 | YOR388C | 1.4 | 2.7 | 2.5 | 2.7 | 11,622 |
Shown in this table are the expression values in FPKM for the 21 subtelomeric genes that increased in expression in sir2Δ, sir3Δ, and sir4Δ. Genes are ordered by chromosome number and map position. FPKM values represent the average of three biological replicates. Distances to nearest Sir peaks were calculated by taking the difference of the midpoint of the gene and the genomic coordinate of the highest nearby Sir protein IP/input enrichment value.