Table 1. Accuracy of parameter estimates using the composite-likelihood, iHS, and nSL methods.
Parameters | Composite likelihood | iHS | nSL | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Ra | α | Statistical power (%)b | mean ± SD | deviation mean (median)c | Exact site detected (%)d | Statistical power (%)b | deviation mean (median)c | Exact site detected (%)d | Statistical power (%)b | deviation mean (median)c | Exact site detected (%)d |
Using both polymorphic and monomorphic sites | |||||||||||
2000 | 1000 | 57 (17) | 1160 ± 660 | 3.68 (1.73) | 9.23 [10.9] | 24 | 5.67 (2.91) | 4.92 [5.29] | 41 | 4.72 (2.23) | 11.1 [13.1] |
2000 | 86 (36) | 2070 ± 920 | 4.11 (2.43) | 10.6 [12.7] | 63 | 6.18 (4.05) | 3.54 [3.22] | 63 | 5.01 (2.95) | 9.4 [11.4] | |
4000 | 97 (30) | 3850 ± 1780 | 6.03 (3.92) | 9.07 [10.7] | 89 | 8.58 (6.09) | 2.61 [2.23] | 76 | 7.10 (4.45) | 6.9 [7.0] | |
4000 | 1000 | 35 (16) | 1290 ± 840 | 2.92 (0.95) | 15.6 [20.4] | 9.6 | 5.71 (1.80) | 7.37 [9.00] | 42 | 3.36 (1.21) | 18.6 [24.5] |
2000 | 75 (40) | 2290 ± 1000 | 2.51 (1.39) | 15.9 [19.2] | 41 | 3.98 (2.30) | 5.46 [6.58] | 73 | 2.77 (1.62) | 16.3 [17.1] | |
4000 | 94 (48) | 4030 ± 1610 | 3.56 (2.20) | 13.8 [16.7] | 78 | 5.12 (3.45) | 3.90 [4.29] | 87 | 3.66 (2.35) | 12.6 [12.4] | |
Using only polymorphic sites | |||||||||||
4000 | 1000 | 4.0 | 860 ± 950 | 3.62 | 13.3 | ||||||
2000 | 36 | 1630 ± 1010 | 3.21 | 13.3 | |||||||
4000 | 82 | 3290 ± 1870 | 4.91 | 10.3 |
Scaled recombination rate (4Nr) across the 100-k-long simulated sequence.
Percentages of simulated samples that yield P < 0.001. In parentheses: using an adjusted recombination rate in neutral simulations to yield mean LD identical to that of data to be analyzed.
Mean (median) deviation in kilobases of the estimated location of selection from the true location (x = 50,000):
Percentages of simulated samples for which = 50,000. Those of samples in which the frequency of the beneficial allele is exactly 10 are given in brackets.