Table 3.

Replication^a of WC–DNA methylation associations in the GOLDN cohort (N = 911), in order of replication P-value

CpG marker	Chr	Nearest gene	ARIC regression coefficient (per 1 SD WC)	ARIC (P-value)	GOLDN regression coefficient (per 1 SD WC)	GOLDN (P-value)	Direction	Combined meta-analysis (P-value)
cg13708645	12	KDM2B	0.0098	7.22E − 11	0.0074	1.28E − 05	++	4.52E − 15
cg11024682	17	SREBF1	0.0080	3.52E − 12	0.0039	1.33E − 05	++	2.37E − 16
cg03078551	17	intergenic	−0.0025	8.16E − 09	−0.0021	1.74E − 05	−−	6.61E − 13
cg06192883	15	MYO5C	0.0083	1.50E − 12	0.0031	2.56E − 05	++	2.15E − 16
cg26403843	5	RNF145	0.0101	2.38E − 09	0.0044	7.53E − 05	++	7.92E − 13
cg13123009	6	LY6G6E	0.0074	1.81E − 13	0.0032	8.25E − 05	++	1.07E − 16
cg06500161	21	ABCG1	0.0096	4.41E − 19	0.0043	9.39E − 05	++	1.09E − 21
cg17901584	1	DHCR24	−0.0080	8.34E − 08	−0.0049	2.39E − 04	−−	8.15E − 11

^aSuccessful replication was defined as consistent direction of association in GOLDN and ARIC and P-value of <0.05/164 (<3 × 10⁻⁴) in the replication cohort. Meta-analysis used Stouffer's Z for trend test, which is based on meta-analysis of P-values with adjustment for cohort sample size and direction.