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. 2015 May 13;24(15):4417–4428. doi: 10.1093/hmg/ddv178

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Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 6. — Rpe65^P25L/P25L KI mouse has full-field scotopic (rod), photopic (cone) ERG responses similar to WT but has delayed a-wave recovery after moderate visual pigment bleach. Dark-adapted (scotopic) ERG (A) and light-adapted (photopic) ERG (B) b-wave responses were obtained from 3-month-old homozygous KI/KI (open circle), heterozygous wt/KI (half-filled circle) and the littermate WT (filled circle) controls. Each point represents the average of six mice. Error bars show ±SD. (C) Cone signal isolation in Rpe65^P25L/P25L KI mouse. B-wave amplitudes in response to a series of flashes varying intensity of UV (triangles) and green light (circles) stimuli were measured for 6-month-old homozygous KI/KI mice, heterozygous wt/KI and the littermate WT controls. Each point represents the average of four mice. Error bars show ±SD. (D) Representative a-wave recovery after moderate visual pigment bleach in KI/KI (open circle), WT (filled circle) and wt/KI (half-filled circle) mice. Continuous curves are plotted from Equation (1) fitted to the data with a nonlinear regression.