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. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Med Chem. 2012 Nov 9;55(22):10022–10032. doi: 10.1021/jm301181r

Scheme 3. Synthesis of Compounds with Different Spacers and Functional Groupsa.

Scheme 3

aReagents and conditions: (a) triethylamine, ethanol, 80 °C, 16 h; (b) 30% TFA in dichloromethane; (c) appropriate isocyanate, triethylamine, THF, rt; (d) acetic anhydride, pyridine; (e) methanesulfonyl chloride, triethylamine, THF.