Skip to main content
. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Med Chem. 2012 Nov 9;55(22):10022–10032. doi: 10.1021/jm301181r

Scheme 4. Synthesis of Compounds with Different Spacers and Functional Groups Continueda.

Scheme 4

aReagents and conditions: (a) 21, ethanol, 80 °C, 16 h; (b) 30% TFA in dichloromethane; (c) appropriate isocyanate, triethylamine, THF; (d) appropriate anhydride, triethylamine, THF; (e) appropriate sulfonyl chloride, triethylamine, THF.