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. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Med Chem. 2012 Nov 9;55(22):10022–10032. doi: 10.1021/jm301181r

Table 1.

Functional Assessment of Compound 9

compd TPSA Ke CB1 (nM) Ki CB1 (nM) [3H] CP55940 Ki CB2 (nM) [3H] CP55940 CB2/CB1 Ki ratio MDCK-mdr1 A to B (%)a
2 102 8.7 40
8   81 0.45 3.44 5504 1600   8
9   90 9 1.79 5507 3077   6
a

Compound’s permeability was measured from apical to basal (A to B) sides of the membrane.