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. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Med Chem. 2012 Nov 9;55(22):10022–10032. doi: 10.1021/jm301181r

Table 2.

Functional Assessment of Analogues of Compound 9

compd TPSA Ke CB1 (nM) Ki CB1 (nM) [3H] CP55940 Ki CB2 (nM) [3H] CP55940 CB2/CB1 Ki ratio MDCK-mdr1 A to B (%)a
10   85 3.9 7.1 13947 1959 <1
11   73 15.9 11 1657 151 <1
12 101 2.9 6.2 948 153 <1
13a   88 19.2 25.5 20000 784 <1
13b   88 443 195 4645 24
13c   88 46 337 8946 27
13d   88 99 220 7779 35
13e   88 62 269 >20000 >74
13f 114 171
13g   88 199
a

Compound’s permeability was measured from apical to basal (A to B) sides of the membrane.