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. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Med Chem. 2012 Nov 9;55(22):10022–10032. doi: 10.1021/jm301181r

Table 3.

Functional Assessment of Different Spacers and Functional Groups

compd TPSA Ke CB1 (nM) Ki CB1 (nM) [3H] CP55940 Ki CB2 (nM) [3H] CP55940 CB2/CB1 Ki ratio
14a   85 92 24 14000 568
14b   68 5706
14c   88 1148
14d   88 495
14e   88 1964
14f   88 71 3343 >20000 >5
14g 101 1645
15a   85 326
15b   68 5546
15c   88 1500
15d   76 920
15e 101 346
16a   85 3927
16b   68 8406
16c   88 1153
16d   76 4449
16e 101 6044
17a   85 11 1.5 1713 1142
17c   88 149
17d   88 133 14 2453 175
17e   88 132 28 153 5
17f   88 49 25 1548 62
17g   76 631
17h 101 71 29 1073 37
17i   76 3.2
17j   76 0.7
17k 101 0.3 1.2 5865 4888