Table 4.
in vitro metabolic stability
|
||||||
---|---|---|---|---|---|---|
compd | TPSA | Ke CB1 (nM) | CB2/CB1 Ki CP55940 | MDCKmdr1 A to B (%) | S9% remaining 120 min | plasma % remaining 60 min |
9 | 90 | 0.45 | 3077 | 6 | >90 | >90 |
12 | 101 | 2.9 | 153 | <1 | >90 | >90 |
13a | 88 | 19.2 | 784 | <1 | 43 | >90 |