Skip to main content
. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Med Chem. 2012 Nov 9;55(22):10022–10032. doi: 10.1021/jm301181r

Table 4.

Functional Assessment of Select Compounds in for in Vitro Metabolic Stability

in vitro metabolic stability
compd TPSA Ke CB1 (nM) CB2/CB1 Ki CP55940 MDCKmdr1 A to B (%) S9% remaining 120 min plasma % remaining 60 min
9   90   0.45 3077 6 >90 >90
12 101   2.9 153 <1 >90 >90
13a   88 19.2 784 <1 43 >90