. Author manuscript; available in PMC: 2015 Jul 6.

Published in final edited form as: J Med Chem. 2012 Nov 9;55(22):10022–10032. doi: 10.1021/jm301181r

Table 5.

Pharmacokinetic Analyses of 12

compd	dose mg/kg oral	sacrifice time (min)	plasma conc. (ng/mL)	brain conc. (ng/mL)	brain/plasma ratio
12	10	30	752	38	0.05
		60	767	58	0.08
		120	1188	122	0.10
		240	1653	184	0.11
		480	914	89	0.10