Table 2. Effects of a 3-week exposure to leptin or estradiol on later mammary carcinogenesis in nulliparous and parous rats.
Treatment | Tumor incidence (%) Weeks after treatment |
Tumor multiplicity (mean±SEM) |
Tumor latency (weeks) (mean±SEM) |
||
---|---|---|---|---|---|
0–22 | 0–12 | 13–22 | |||
Nulliparous rats | |||||
Control | 17/29 59% |
7/17 41% |
10/17a 59% |
1.88 ± 0.40 | 13.29 ± 1.09 |
Leptin | 14/28 50% |
11/14 79% |
3/14b 21% |
1.43 ± 0.14 | 11.14 ± 1.22 |
Estradiol | 22/41 54% |
5/22 23% |
17/22c 77% |
1.73 ± 0.24 | 14.9 ± 0.84 |
Parous rats | |||||
Control | 14/43b 32% |
13/14 93% |
1/14a 7% |
1.93 ± 0.29 | 7.07 ± 0.76a |
Leptin | 26/40a 65% |
14/26 54% |
12/26b 46% |
1.33 ± 0.12 | 12.27 ± 1.11b |
Estradiol | 19/42a,b 45% |
9/19 47% |
10/19b 53% |
1.37 ± 0.18 | 12.31 ± 1.38b |