Table 3.
Genes downregulated in parous rats treated with E2 or leptin during pregnancy, compared to vehicle exposed parous rats
| Gene Name | Symbol | Accession # | Function | Category | Fold |
|---|---|---|---|---|---|
| Cytochrome c oxidase, subunit Va | Cox5a | rc_AI104513_at | Electron transport | Metabolism | 0.41 |
| Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Gne | rc_AI145931_at | Amino sugar biosynthesis | Metabolism | 0.49 |
| Parathymosin | Ptms | M33025_s_at | Regulation of glycolysis | Metabolism | 0.34 |
| Acidic nuclear phosphoprotein 32 family, member A | Anp32a | rc_AI070967_at | Nucleocytoplasmic transport | Transporter/differentiation | 0.42 |
| Apolipoprotein E | Apoe | X04979_at | Lipid transport | Transporter | 0.42 |
| Aquaporin 5 | Aqp5 | U16245_g_at | Carbon dioxide and water transport | Transporter | 0.42 |
| Calcium channel, voltage-dependent, L type, alpha 1D subunit | Cacna1d | D38101_s_at | Calcium ion transport | Transporter | 0.47 |
| Epsin 2 | Epn2 | AF096269_at | Endocytosis/Notch signal transduction | Transporter/ signal transduction/ embryonic development | 0.4 |
| Ferritin light polypeptide | Ftl1 | rc_AI231807_g_at | Iron transport | Transporter | 0.44 |
| Lectin, galactoside-binding, soluble, 9 | Lgals9 | U72741_at | Ion transport/NFκB signaling | Transporter/Signal Transduction | 0.41 |
| Low density lipoprotein receptor-related protein 3 | Lrp3 | AB009463_g_at | Lipoprotein receptor/endocytosis | Transporter | 0.43 |
| PDZK1 interacting protein 1 | Pdzk1ip1 | rc_AA892264_at | Glucose transport | Transporter | 0.37 |
| Rab38, member RAS oncogene family | Rab38 | rc_AI136175_at | Vesicle mediated transport | Transporter | 0.37 |
| Secretogranin V (7B2 protein) | Scg5 | M63901_g_at | Regulation of hormone secretion | Transporter | 0.34 |
| Sodium channel, nonvoltage-gated 1 gamma | Scnn1g | X77933_at | Sodium ion transport | Transporter | 0.47 |
| Integrin beta 4 | Itgb4 | U60096_at | Integrin signaling | ECM/cell motility | 0.49 |
| Syndecan 4 | Sdc4 | S61868_g_at | Focal adhesion assembly | ECM | 0.5 |
| Transforming growth factor, beta 3 | Tgfb3 | U03491_g_at | Growth Factor | ECM/EMT | 0.34 |
| Tropomyosin 3, gamma | Tpm3 | L24776_at | Actin binding | Structural | 0.11 |
| Troponin T type 2 cardiac | Tnnt2 | M80829_at | Actin binding | Muscle contraction | 0.35 |
| Alpha-2-macroglobulin | A2m | X13983mRNA_at | Inflammatory response | Immune | 0.33 |
| Granzyme F | Gzmf | U57063_at | Protease | Immune | 0.45 |
| Kininogen 1 | Kng1 | K02814_g_at | Inflammatory response | immune | 0.47 |
| Lipopolysaccharide binding protein | Lbp | L32132_at | Inflammatory response | Immune | 0.43 |
| Lipocalin 2 | Lcn2 | rc_AA946503_at | Protease and iron binding/ transporter | Immune/Apoptosis | 0.47 |
| Myxovirus (influenza virus) resistance 2 | Mx2 | X52713_at | Antiviral | Immune | 0.36 |
| Protein tyrosine phosphatase, non-receptor type 1 | Ptpn1 | M33962_at | Endocytosis/Insulin receptor signaling | UPR/Signal Transduction | 0.5 |
| Heat shock protein 1A | Hspa1a | Z27118cds_s_at | Stress-inducible chaperone | UPR/Antiproliferative | 0.35 |
| B-cell CLL/lymphoma 2 | Bcl2 | L14680_g_at | Intrinsic apoptotic pathway | Antiapoptosis | 0.5 |
| Cystatin C | Cst3 | rc_AI231292_g_at | Cystein protease inhibitor | Apoptotsis | 0.49 |
| Guanine nucleotide binding protein (G protein), beta polypeptide 1 | Gnb1 | U88324_at | GTPase | Apoptosis/Proliferation/Signal transduction | 0.33 |
| G protein-coupled receptor kinase 1 | Grk1 | U63971_at | G protein coupled receptor signaling | Apoptosis/Signal transduction | 0.36 |
| Nitric oxide synthase 3, endothelial cell | Nos3 | U02534_at | NO synthesis | Apoptosis/Angiogenesis | 0.42 |
| SMAD family member 3 | Smad3 | U66479_at | Transcription factor/ TGFβ signaling | Apoptosis/ Signal transduction | 0.48 |
| Adrenergic receptor, alpha 2b | Adra2b | M32061_at | G-protein coupled receptor | Signal transduction/ Angiogenesis | 0.43 |
| ArfGAP with dual PH domains 1 | Adap1 | U51013_at | Inositol phosphate-mediated signaling | Signal transduction | 0.48 |
| Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 | Cited1 | AF104399_g_at | Transcription factor/ Estrogen receptor- and TGFβ signaling | Signal Transduction | 0.48 |
| GNAS complex locus | Gnas | L10326_at | G-protein alpha subunit | Signal transduction/ differentiation | 0.48 |
| G protein-coupled estrogen receptor 1 | Gper | U92802_at | Estrogen receptor activity | Signal Transduction | 0.43 |
| Guanylate cyclase 1, soluble, beta 2 | Gucy1b2 | M57507_at | Guanylate cyclase | Signal transduction | 0.31 |
| High mobility group box 1 | Hmgb1 | rc_AI029805_at | Transcription Factor/cytokine | Signal transduction/immune | 0.38 |
| Mitogen activated protein kinase kinase 1 | Map2k1 | rc_AI178835_at | MAPK signaling | Signal Transduction/ Differentiation | 0.45 |
| Prepronociceptin | Pnoc | S79730_s_at | Opiod-like orphan receptor ligand | Signal transduction | 0.43 |
| Ret proto-oncogene | Ret | AF042830_at | Proto-oncogene/ receptor tyrosine kinase | Signal transduction/ embryonic development | 0.45 |
| Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | Ywhae | rc_AA965154_at | Calcium/ calmodulin- dependent signal transduction | Signal transduction | 0.48 |
| Brain abundant, membrane attached signal protein 1 | Basp1 | D14441_at | Transcriptional corepressor | Differentiation | 0.46 |
| Ceruloplasmin (ferroxidase) | Cp | Y12178_at | Copper transport | Differentiation | 0.44 |
| Casein alpha s1 | Csn1s1 | J00710_at | Milk protein | Differentiation | 0.46 |
| D4, zinc and double PHD fingers family 1 | Dpf1 | X66022mRNA#3_i_at | Transcription factor | Differentiation | 0.41 |
| Jun-B proto-oncogene | Junb | X54686cds_at | Transcription factor/proto-oncogene | Differentiation/response to hormone stimulus | 0.34 |
| Keratin 19 | Krtt19 | X81449cds_at | Keratin | Differentiation/response to estrogen stimulus | 0.36 |
| Lactalbumin alpha | Lalba | X00461_at | Lactose biosynthesis | Differentiation | 0.49 |
| Growth hormone releasing hormone | Ghrh | U41183_at | Growth hormone receptor binding | Growth factor | 0.31 |
| H3 histone, family 3B | H3f3b | rc_AA875069_at | Nucleosome assembly | Reponse to hormone stimulus/gene expression | 0.25 |
| Prolactin family 8, subfamily a, member 4 | Prl8a4 | AB009889_f_at | Hormone activity | Hormone | 0.32 |
| FEV (ETS oncogene family) | FEV | U91679_at | Transcription factor | Gene expression | 0.48 |
| Forkhead box O1A | Foxo1a | rc_AA893671_at | Transcription factor | Gene expression/proliferation/Antiapoptosis | 0.46 |
| Proline-rich nuclear receptor coactivator-1 | Pnrc1 | rc_AI235492_at | Nuclear receptor coactivator | Gene expression | 0.45 |
| Ribosomal protein L10 | Rpl10 | rc_AA945611_at | Translation | Gene expression | 0.48 |
| Ribosomal protein L30 | Rpl30 | D84480_s_at | Translation | Gene expression | 0.47 |
| Ribosomal protein S14 | Rps14 | rc_AA945806_at | Translation | Gene expression/ differentiation | 0.49 |
| Calpain 8 | Capn8 | D14478_s_at | Proteolysis | Protein regulation | 0.39 |