Table 2.

%NENH of the Abdominal Aortic Wall and Liver Relative to Muscle as a Function of Micelle Formulation and Time After Injection in ApoE^−/− Mice

	Time After Injection, h
	24	48	72
%NENH vessel wall of ApoE−/− mice
MDA2 micelles (n=8)	60±9*	90±3*	125±22*
E06 micelles (n=8)	93±54*	88±7*	231±40*
IK17 micelles (n=3)	82±40*	95±49*	138±35*
IgG micelles (n=3)	3±33	−8±9	−0.6±29
Untargeted micelles (n=8)	20±18	2±20	15±10
Competitive inhibition (n=3)	43±24	33±18	20±15
%NENH in liver of ApoE−/− mice
MDA2 micelles (n=8)	34±18	34±7	33±4
E06 micelles (n=8)	39±10	40±9	49±17
IK17 micelles (n=3)	27±6	42±10	38±6
IgG micelles (n=3)	27±10	10±9†	−4±4‡
Untargeted micelles (n=8)	38±5	42±5	39±10
Competitive inhibition (n=3)	8±3†	−8±8*	−8±8†

^*P<0.001,

^†P<0.01,

^‡P<0.05 vs untargeted micelles.