Fig 1. SmLy6 members demonstrate feature conservation characteristic of the uPAR/Ly6 superfamily.

PSI-BLAST querying was used to identify eleven Ly6 family members in the S. mansoni genome (v 5.0). A) Diagrammatic representation of protein features characteristic of a single domain Ly6 protein. B) MUSCLE alignment of the deduced full-length amino acid sequences of SmLy6A—K sequences (SmLy6D sequence is split into SmLy6D 1^st and 2^nd domains). Predicted signal peptide sequences are highlighted in red. Conserved cysteines are shaded in yellow and labelled C¹ to C¹⁰. Predicted GPI anchor sites are shaded in green and hydrophobic regions are highlighted in blue. The four amino acids shown to be essential in HsCD59 function [47] are indicated on the sequence by boxes. The amino acid numbering (indicated at left of alignment) begins at the initiating M of each protein.