Table 1.
Clinical effects according to medical assessment
| Parameter | Day 60
|
Day 90
|
Day 120
|
Day 150
|
Day 180
|
Day 210
|
P-value in relation to day 60
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | N | % | N | % | Day 90 | Day 120 | Day 150 | Day 180 | Day 210 | |
| Wrinkles | 20 | 49.00 | 33 | 80.00 | 27 | 66.00 | 22 | 54.00 | 13 | 32.00 | 23 | 56.00 | 0.003 | 0.108 | 0.670 | 0.108 | 0.549 |
| Fine lines | 20 | 49.00 | 33 | 80.00 | 30 | 73.00 | 21 | 51.00 | 13 | 32.00 | 23 | 56.00 | 0.003 | 0.025 | 0.835 | 0.108 | 0.549 |
| Solar melanosis | 16 | 39.00 | 31 | 76.00 | 14 | 34.00 | 9 | 22.00 | 5 | 12.00 | 13 | 32.00 | 0.001 | 0.655 | 0.108 | 0.005 | 0.467 |
| Other hyperchromias | 18 | 44.00 | 29 | 71.00 | 16 | 39.00 | 11 | 27.00 | 6 | 15.00 | 13 | 32.00 | 0.016 | 0.655 | 0.071 | 0.003 | 0.251 |
| Erythema | 15 | 37.00 | 24 | 59.00 | 9 | 22.00 | 7 | 17.00 | 9 | 22.00 | 22 | 54.00 | 0.071 | 0.532 | 0.317 | 0.513 | 0.018 |
| Hydration | 31 | 76.00 | 41 | 100.00 | 40 | 98.00 | 39 | 95.00 | 41 | 100.00 | 40 | 98.00 | – | 0.003 | 0.011 | – | 0.007 |
| Radiance | 31 | 76.00 | 41 | 100.00 | 38 | 93.00 | 38 | 93.00 | 41 | 100.00 | 40 | 98.00 | – | 0.020 | 0.020 | – | 0.007 |
| Sebum | 17 | 41.00 | 39 | 95.00 | 31 | 76.00 | 23 | 56.00 | 32 | 78.00 | 23 | 56.00 | <0.001 | 0.002 | 0.134 | 0.003 | 0.109 |
| Smoothness | 31 | 76.00 | 41 | 100.00 | 39 | 95.00 | 39 | 95.00 | 40 | 98.00 | 41 | 100.00 | – | 0.011 | 0.021 | 0.007 | – |
| Overall appearance | 34 | 83.00 | 41 | 100.00 | 40 | 98.00 | 38 | 93.00 | 41 | 100.00 | 40 | 98.00 | – | 0.035 | 0.132 | – | 0.035 |