Table 3.

Effect of Standard DNA Conformation on AAV8 Titer Quantitation

Titer (VG/ml) (n=9)	Target sequence	Titer (VG/ml) circular standards	Titer (VG/ml) linear standards
Batch 1	ITR	2.48±1.26×109	2.81±1.53×109
	GFP	4.80±0.74×109	2.15±0.35×109
	CMV	2.35±1.03×109	2.96±1.48×109
Batch 2	ITR	1.41±0.33×108	1.41±0.39×108
	GFP	1.14±0.59×108	4.19±2.33×108
	CMV	7.43±0.54×108	1.10±0.79×108
Batch 3	ITR	4.08±2.57×107	3.45±2.16×107
	GFP	3.08±2.83×107	8.41±0.76×106
	CMV	2.48±1.28×107	4.18±0.40×107

GFP, green fluorescent protein; VG, vector genomes.