Table S1.
Detection thresholds for UVS, MPS, AAS, and SSc
| Quantification method | Detection threshold unit (ø+3σ) | SEONLA | SEONLA-BSA | Rienso® |
|---|---|---|---|---|
| UVS | (µgFe/mL) | 4.47 | 4.74 | 4.03 |
| MPS | (µgFe/mL) | 0.49 | 0.31 | 2.52 |
| AAS | (µgFe/mL) | 0.56 | 0.56 | 0.56 |
| SSc | (%) | 110.48 | 109.16 | 112.11 |
Notes: Detection threshold for the UVS, MPS, and AAS techniques with SPION-containing cell lysates indicated as µgFe/mL cell lysate. The detection threshold for SSc analysis is indicated as the percentage compared with SSc data of untreated cells. The thresholds for UVS, MPS, and SSc is dependent on the SPION nature, whereas AAS, a method quantifying elementary iron, is not. Determinations of the detection threshold were achieved using the 3σ criteria.
Ø, mean value of the negative control; σ, standard deviation.
Abbreviations: UVS, ultraviolet spectrophotometry; MPS, magnetic particle spectroscopy; AAS, atomic adsorption spectroscopy; SSc, side scatter analysis; SEONLA, lauric acid-coated nanoparticles; SEONLA-BSA, lauric acid/albumin bovine serum hybrid-coated nanoparticles; SPION, superparamagnetic iron oxide nanoparticle.