Table 3.
Article-related index of change for topics on pain modulators and their molecular targets
| Number | Topic | Index of change
|
|||||
|---|---|---|---|---|---|---|---|
| 1984–1988 | 1989–1993 | 1994–1998 | 1999–2003 | 2004–2008 | 2009–2013 | ||
| 1 | Purinergic receptors | >100a | 48 | 95 | 86 | 61 | >100 |
| 2 | Serotonin | 36 | 67 | 65 | 83 | 10 | −3 |
| 3 | Bradykinin | 12 | 92 | 13 | 54 | 16 | −17 |
| 4 | Substance P | 77 | 59 | 21 | 28 | 13 | −6 |
| 5 | TRP channels | 46 | >100 | 78 | >100 | 96 | 45 |
| 6 | Calcium channels | – | >100 | >100 | >100 | >100 | 30 |
| 7 | Cholecystokinin | >100 | 15 | 32 | 33 | −24 | −27 |
| 8 | Cytokines | >100 | >100 | >100 | >100 | 79 | 65 |
| 9 | GABA | 87 | 43 | >100 | >100 | 91 | 46 |
| 10 | Glutamate | >100 | >100 | >100 | 84 | 62 | 1 |
| 11 | Botulinum toxins | – | >100 | >100 | >100 | 93 | 23 |
| 12 | Cannabinoids | – | >100 | >100 | >100 | >100 | 17 |
| 13 | CGRP | – | >100 | 63 | 81 | 74 | 44 |
| 14 | Neurotrophins | – | – | >100 | >100 | 39 | 58 |
| 15 | Nitric oxide synthase | – | – | >100 | 82 | 32 | 40 |
| 16 | Protein kinases | – | >100 | >100 | >100 | >100 | 75 |
| 17 | VGSC | – | – | – | >100 | >100 | 58 |
Notes: Article-related index of change is the percentage change in number of published articles on a specific topic during a 5-year period compared with the previous similar period;
a
>100, indicates more than 100%.
Abbreviations: TRP, transient receptor potential; GABA, gamma aminobutyric acid; CGRP, calcitonin gene-related peptide; VGSC, voltage-gated sodium channels.