Table 3.

Proteins highly discriminating patients from healthy controls, in descending order of importance according to variable influence on projection (VIP)

Proteins	Spot number	UniProt accession number	pI	Mw kDa	VIP	Spot optical density quotienta
Angiotensinogen, isoform	3409	P01019	5.70	79.3	2.88	4.83
Alpha-1-antitrypsin, isoform	5106	P01009	6.5	19.4	2.48	0.72
LysoPLD, isoformb	6705	Q13822	8.2	108.0	2.38	0.28
Alpha-1-antitrypsin, isoform	1505	P01009	5.44	97.5	2.32	0.11
Leucine-rich alpha-2-glycoprotein, isoformc	203	P02750	4.9	62.1	2.11	2.20
Haptoglobin, isoform	1211	P00738	5.40	56.6	2.09	2.46
Haptoglobin, isoform	1203	P00738	5.25	57.6	2.09	3.66
Haptoglobin, isoform	2205	P00738	5.45	55.5	2.03	2.11
Pigment epithelium-derived factor, isoform	3308	P36955	5.62	65.7	2.02	0.83
Transthyretin, isoform	1011	P02766	5.40	12.1	1.98	1.28
Alpha-1-antitrypsin, isoform	1308	P01009	5.35	69.6	1.97	1.08
Hemopexin, isoform	3605	P02790	5.68	99.4	1.96	0.25
Plasminogen, isoform	8802	P00747	9.5	144.6	1.90	0.77
Apolipoprotein A-I, isoform	3102	P02647	5.77	22.6	1.89	3.33
Alpha-1-antitrypsin, isoformd	2601	P01009	5.54	153.0	1.89	0.53
Alpha-1-antitrypsin, fragment	111	P01009	5.10	38.9	1.85	1.92
Clusterin	3108	P10909	5.78	44.3	1.81	0.22
Prothrombin, isoforme	1607	P00734	5.25	124.4	1.79	0.76
Apolipoprotein A-I, isoform	2001	P02647	5.45	22.1	1.76	1.26
Gelsolin	4609	P06396	6.18	129.2	1.74	0.29
Retinol-binding protein 4	1006	P02753	5.44	16.7	1.71	1.42
Apolipoprotein A-I, isoform	3010	P02647	5.65	18.0	1.68	6.35
Prostaglandin-H2 D-isomerase, isoform	112	P41222	5.20	28.3	1.67	4.69
Haptoglobin, isoform	1201	P00738	5.10	57.6	1.65	1.69
Alpha-1-antitrypsin, isoform	1310	P01009	5.25	70.9	1.65	1.13
Apolipoprotein A-I, isoform	2010	P02647	5.58	15.2	1.62	10.58
Prostaglandin-H2 D-isomerase, isoform	6106	P41222	6.65	25.7	1.62	0.72
Complement factor B Bb, fragment	2312	P00751	5.35	46.9	1.59	1.79
Alpha-1-antitrypsin, isoform	2311	P01009	5.39	69.6	1.58	1.09
Apolipoprotein E, isoform	3107	P02649	5.8	37.4	1.53	0.78
Albumin	5619	P02768	5.95	105.1	1.52	0.65
Protein AMBP	1103	P02760	5.35	31.6	1.50	2.09

Notes:

^aQuotient of median values of patients and healthy controls (patients/healthy controls);

^bthere are ~50% missing values in both patients and controls;

^cthere are ~20% missing values in both patients and controls;

^dthere are 46% missing values in patients and 82% in controls;

^ethere are 55% missing values in patients and 18% in controls.

Abbreviations: UniProt, Universal Protein Resource; pI, isoelectric point; Mw, molecular weight.