Effect of the treatment of mice with tetraethylammonium (TEA; 25 pg/site, i.c.v.; A), glibenclamide (0.5 pg/site, i.c.v.; B), charybdotoxin (25 pg/site, i.c.v.; C), or apamin (10 pg/site, i.c.v.; D) in combination with a subeffective dose of hesperidin (0.01 mg/kg, i.p.) in the TST. Each value is expressed as the mean±S.E.M. (n=7 mice in each group). Asterisks represent significant effect (**P<.01; ***P<.001) when compared with the respective vehicle-treated control group. i.c.v., intracerebroventricular; i.p., intraperitoneally; S.E.M., standard error of the mean; TST, tail suspension test.