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. 2015 Jul 10;23(2):148–162. doi: 10.1089/ars.2014.6151

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Copyright 2015, Mary Ann Liebert, Inc.

© Jayne Louise Wilson et al. 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 9. — Coherence plot showing transcription factors (TFs) involved in the response to CORM-3 versus iCORM-3 in hemA cells. The x-coordinate of each point represents the “profile difference” between the two conditions (computed as 1 minus the absolute Pearson correlation coefficient between the two profiles), while the y-coordinate represents the change in magnitude of the response (computed as the difference of the norm of the two profiles). Hence, TFs whose response is similar in both magnitude and kinetics will be located near the origin of the coherence plot in quadrant C, while TFs in quadrant B of the plot respond very differently both in terms of kinetics and in terms of amplitude. The activity of the TF BaeR in hemA cells is similar in response to both iCORM-3 and CORM-3, whereas HNS and NarP respond differently when cells are exposed to iCORM-3 or CORM-3.