Table 1.
Absolute Pearson Correlations Comparing Transcription Factors of Interest
hemA CORM-3 vs. iCORM-3 | Wild type vs. hemA (CORM-3) | |||
---|---|---|---|---|
Transcription factor name | Mean absolute Pearson correlation | Standard deviation of correlation | Mean absolute Pearson correlation | Standard deviation of correlation |
BaeR | 0.968 | 0.017 | 0.810 | 0.043 |
CpxR | 0.718 | 0.039 | 0.959 | 0.008 |
CRP | 0.829 | 0.019 | 0.814 | 0.014 |
CysB | 0.570 | 0.034 | 0.535 | 0.036 |
Fis | 0.715 | 0.030 | 0.860 | 0.023 |
FNR | 0.807 | 0.014 | 0.766 | 0.013 |
Fur | 0.630 | 0.019 | 0.987 | 0.004 |
GadX | 0.927 | 0.037 | 0.064 | 0.048 |
H-NS | 0.223 | 0.043 | 0.859 | 0.024 |
IHF | 0.873 | 0.015 | 0.862 | 0.014 |
IscR | 0.324 | 0.055 | 0.812 | 0.036 |
NarL | 0.759 | 0.052 | 0.382 | 0.246 |
NarP | 0.479 | 0.249 | 0.386 | 0.240 |
NsrR | 0.745 | 0.047 | 0.820 | 0.067 |
OxyR | 0.244 | 0.089 | 0.889 | 0.037 |
SoxS | 0.177 | 0.132 | 0.814 | 0.111 |
Mean absolute Pearson correlation values are given for transcription factor activity profiles in the heme-deficient mutant of Escherichia coli (hemA) treated with CORM-3 versus iCORM-3 and the heme-deficient mutant versus wild-type after exposure to CORM-3. Values close to 1 indicate transcription factors that exhibit a similar pattern of activity over 2 h post-treatment of heme-deficient or wild-type E. coli with the compound. Listed also is the resulting standard deviation of the absolute Pearson correlation.