Fig. 3.

VCP/p97 post-translational modifications. Linear representation of the VCP/p97 protein with N-terminal (N) domain and dual ATPase domains D1 and D2. All reported PTMs are marked according to a color code: tyrosine phosphorylation (Y-P) in dark blue, threonine phosphorylation (T-P) in light blue, serine phosphorylation (S-P) in green, ubiquitination (U) in red, acetylation (A) in orange and all others modifications in purple. Lysine methylation (M) and S-thionylation (T; a broad term which serves to describe a number of redox modifications that take place on the sulfur group of cysteine residues including disulfide oxidation, S-nitrosylation and S-glutathionylation) are among the infrequent modifications reported here. The majority of the data was provided by the public PTM database PhosphoSitePlus (http://www.phosphosite.org) and also from various sources in the scientific literature. PTMs identified on the basis of a single mass spectrum or reported in a single article are denoted with an asterisk.