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Estimated pharmacokinetic parameters for (2S,6S)-HNK after i.v and p.o administration of 20 mg/kg (2S,6S)-HNK(±SD).
| Protocol | Compound | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUClast (h·ng/mL) | AUCinf (h·ng/mL) | Vss (mL/kg) | Cl (mL/h per kg) |
|---|---|---|---|---|---|---|---|---|
| (2S,6S)-HNK | ||||||||
| i.v. | (2S,6S)-HNK | 8 ± 4.0 | NA | 14,754 ± 694 | 28,981 ± 6162 | 29,242 ± 6421 | 6163 ± 475.7 | 1951 ± 692 |
| p.o. | (2S,6S)-HNK | 3.78 ± 0.64 | 0.42 ± 0.14 | 4713 ± 1221 | 10,120 ± 1313 | 13,551 ± 1665 | NC | |
