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. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Neurochem. 2010 Jan 28;113(2):552–561. doi: 10.1111/j.1471-4159.2010.06625.x

Fig. 5.

Fig. 5

Effect of systemic (i.p.) pregabalin pretreatment on behavioral nociceptive scores in the formalin test. Repeated measures ANOVA reveals a significant main effects of i.p. pregabalin dose (F(3,22) = 3.21, p < 0.05) and time (F(11,242) = 22.5, p < 0.001), but a non-significant dose X time interaction (F(33,242) = 1.27 p > 0.05). Post hoc comparison revealed that compared to vehicle (n=6), formalin test nociceptive scores were significantly reduced by 100 mg/kg pregabalin (n=8) at 5, and 20–35 min post-formalin, and by 30 mg/kg pregabalin (n=6) at only 20 min post-formalin, while 10 mg/kg (n=6) was without effect.