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Different lung retention by inhaled A2a agonists. Percentage of dose remaining in lung tissue following intratracheal administration of CGS21680, UK-432,097 and Compounds 1, 2 and 3 to rats. The dose was 300 μg/kg for CGS21680, 130 μg/kg for UK-432,097 and 17, 17 and 20 μmol/kg for Compounds 1, 2, and 3, respectively. Data are means of n = 2/time point.
