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Twenty-four hours pre-treatment optimizes the anti-inflammatory effect by compound 2 given i.t. Amount of neutrophils in BAL fluid in saline-treated (open circles), LPS-challenged (closed circles) and compound 2-treated rats at 10 μg/kg; 36 h (open triangles), 24 h (open diamonds) or 12 h (open squares) prior to the LPS challenge. Data is shown as individual values with group averages as a dash.
