Figure 7.

Increased and repeated doses of compound 2 increases the anti-inflammatory efficacy. Single dosing of compound 2 induced a dose-dependent decrease in the LPS-induced recruitment of neutrophilia to the lung by up to 39% (n.s.) at 10 μg/kg (dark grey bar vs. LPS-challenged controls in black bar). Repeated dosing at 10 μg/kg for 3–5 days increased the efficacy of the compound to a statistically significant effect vs. time-matched controls (not shown) of 53% after 5 days of dosing (P = 0.01). Data are shown as Mean±SEM.