Figure 8.

Tachycardia comes before hypotension as the plasma concentration of compound 2 increases. Blood pressure (white bars) and heart rate (black bars) in 6 conscious rats during a 4-step intravenous escalating design (Dose 1–4, equivalent to 1.9, 11, 67, and 410 μg/kg per min) followed by 120 min of washout (WO 10–120) demonstrated baroreflex-compensated hypotension in response to compound 2. The dotted and solid lines represent an untreated time-match control rat in the same setting. Data are Mean±SEM for the last 5 min at each dose level.