Table 2.
Effect of Saroglitazar in Zucker fa/fa rats.
| Group | Triglycerides (mg/dL) | OGTT:AUC glucose (mg/dL · min) |
|---|---|---|
| Control | 441.2 ± 81.7 | 28798.3 ± 3038.3 |
| Saroglitazar (0.01 mg/kg) | 453.1 ± 59.9 | 28970.9 ± 2045.1 |
| Saroglitazar (0.03 mg/kg) | 355.4 ± 29.5 | 28269.1 ± 1214.2 |
| Saroglitazar (0.1 mg/kg) | 316.1 ± 46.1 | 23709.1 ± 2683.8 |
| Saroglitazar (0.3 mg/kg) | 186.5 ± 13.7* | 18941.6 ± 1870.3* |
| Saroglitazar (1 mg/kg) | 93.6 ± 11.0* | 16637.5 ± 1591.5* |
| Saroglitazar (3 mg/kg) | 68.0 ± 3.0* | 13972.6 ± 436.1* |
| Saroglitazar (10 mg/kg) | 55.5 ± 4.1* | 13963.1 ± 548.9* |
Serum triglyceride levels were measured at the end of treatment (14th day) and AUC was measured on day 15th after oral glucose tolerance test, all values expressed as mean ± SEM. (n = 6).
ED50Value for TG reduction – 0.26 mg/kg.
*
P < 0.05 as compared to control (ANOVA).