Table 5.
Effect of Saroglitazar on high fat-high cholesterol (HF-HC) diet fed syrian golden hamsters.
| Group | Triglycerides (mg/dL) | Total cholesterol (mg/dL) | Body weight (g) |
|---|---|---|---|
| Normal diet control | 129.1 ± 9.3 | 78.3 ± 3.0 | 113.7 ± 5.1 |
| HF-HC diet Control | 493.2 ± 77.8 | 306.2 ± 27.7 | 105.3 ± 4.4 |
| Saroglitazar (0.03 mg/kg) | 634.4 ± 87.5 | 392.1 ± 13.5 | 106.4 ± 2.3 |
| Saroglitazar (0.1 mg/kg) | 354.3 ± 59.7 | 293.1 ± 16.7 | 112.6 ± 4.7 |
| Saroglitazar (0.3 mg/kg) | 371.0 ± 35.7 | 315.1 ± 13.1 | 107.1 ± 6.3 |
| Saroglitazar (1 mg/kg) | 272.5 ± 28.0 | 311.4 ± 30.8 | 103.0 ± 4.1 |
| Saroglitazar (3 mg/kg) | 109.9 ± 14.8* | 243.6 ± 24.7 | 100.1 ± 3.6 |
| Saroglitazar (10 mg/kg) | 50.5 ± 7.2* | 144.7 ± 6.6* | 81.6 ± 3.0* |
All values are measured at the end of treatment (14th day), and expressed as mean ± SEM (n = 6).
ED50Values: TG reduction – 0.37 mg/kg.
*
P < 0.05 as compared to control (ANOVA).