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In the dorsal horn of lumbar (L4-L6) spinal cord of vehicle-treated RR-EAE mice, TrkB is colocalized predominantly with (A) BDNF and (B) CD3+ T cells. It is also colocalized with a subset of (C) neurons (NeuN) and to a lesser extent with (D) microglia/macrophages (Iba-1) and (E) minimally with astrocytes (GFAP). Scale bars represent 20 μm; BDNF, brain-derived neurotrophic factor; TrkB, tyrosine kinase B.
