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Positive modulation between hFFA2 agonists. Orthosteric agonist (Propionate; C3), allosteric agonist (4-CMTB) and the acid N-thiazolylamide compound 14 were combined in the hFFA2 yeast assay: (A) C3 plus 4-CMTB, (B) C3 plus compound 14, and (C) 4-CMTB plus compound 14 (representative experiments are shown). (D) Comparison of ΔpEC50 for agonist combinations C3 and 14 and 4-CMTB and 14 (n = 4 or 5 experiments). 4-CMTB, 4-chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide.
