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Acetylcholine-induced relaxations of superior mesenteric arteries of (Upper) WKY and (Lower) SHR at various ages in the presence of indomethacin (cyclooxygenase inhibitor; 10−5 mol/L) and L-NAME (nitric oxide synthase inhibitor; 10−4 mol/L). Values are means ± SEM of six to eight experiments. *P < 0.05 compared with corresponding 12-week-old groups.
