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Effect of inhibition of SIRT1 on EDH-type relaxation in 12-week-old (Left) WKY and (Right) SHR superior mesenteric arteries. Arteries were incubated with EX-527 (SIRT1 inhibitor; 10−6 mol/L) for 40 min in the presence of indomethacin (cyclooxygenase inhibitor; 10−5 mol/L) and L-NAME (nitric oxide synthase inhibitor; 10−4 mol/L). Values are means ± SEM of six experiments. *P < 0.05 compared to the control.
