Table 1.
Comparison of DDX3 expression with clinical parameters and survival analysis
| A | ||||||
|---|---|---|---|---|---|---|
| Average | Cytoplasmic DDX3 | Nuclear DDX3 | ||||
| Low (0–1) | High (2–3) | P-value | < 10% | ≥ 10% | P-value | |
| N | 32 | 63 | 90 | 5 | ||
| Mean age (range) | 61.6 (36–78) | 63.3 (38–79) | 0.443# | 62.4 (36–79) | 67.8 (58–79) | 0.249# |
| Mean tumor size (range) | 4.2 (1.3–10.0) | 3.8 (0.9–10.0) | 0.380# | 4.0 (0.9–10.0) | 3.5 (1.6–4.7) | 0.612# |
| Histological type | ||||||
| Small cell carcinoma | 33.3% (2) | 66.7% (4) | 0.481 | 100% (6) | 0% (0) | 0.075 |
| Squamous cell carcinoma | 27.8% (10) | 72.2% (26) | 86.1% (31) | 13.9% (5) | ||
| Adenocarcinoma | 46.4% (13) | 53.6% (15) | 100% (28) | 0% (0) | ||
| Other | 31.8% (7) | 68.2% (15) | 100% (22) | 0% (0) | ||
| Grade | ||||||
| 1 | 0% (0) | 100% (2) | 0.758 | 100% (2) | 0% (0) | 0.560 |
| 2 | 37.5% (12) | 62.5% (20) | 90.6% (29) | 9.4% (3) | ||
| 3 | 37.5% (12) | 62.5% (20) | 96.9% (31) | 3.1% (1) | ||
| 4 | 25% (3) | 75% (9) | 100% (12) | 0% (0) | ||
| Gender | ||||||
| Male | 35.1% (27) | 64.9% (50) | 0.770 | 93.5% (72) | 6.5% (5) | 0.583$ |
| Female | 31.2% (5) | 68.8% (11) | 100% (16) | 0% (0) | ||
| Stage (pathologic) | ||||||
| I & II | 38.9% (21) | 61.1% (33) | 0.403 | 92.6% (50) | 7.4% (4) | 0.571$ |
| III & IV | 28.6% (6) | 71.4% (15) | 100% (21) | 0% (0) | ||
| B | ||||
|---|---|---|---|---|
| Variables | Univariate | Multivariate | ||
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Tumor size | 1.078 (0.940–1.236) | 0.283 | ||
| Histological type | 1.579 (0.846–2.950) | 0.152 | 1.488 (0.759–2.916) | 0.247 |
| Grade | 1.418 (0.954–2.108) | 0.084 | 1.367 (0.939–1.991) | 0.102 |
| Cytoplasmic DDX3 | 2.103 (1.126–3.930) | 0.020 | 2.136 (1.078–4.233) | 0.030 |
(A) Baseline characteristics of differentially expressed cytoplasmic and nuclear DDX3 in lung cancer patient samples (P-values are determined by chi-square test unless otherwise indicated: # = t-test; $ = Fisher's exact test). (B) Univariate and multivariate cox regression analyses in lung cancer patient samples on clinically relevant variables related to aggressiveness (tumor size, histological type, and grade). Tumor size was not used in multivariate regression analysis as it has a univariate P-value > 0.2 and made the multivariate regression model less predictive.