Table 2.
Blood toxicity studies
| Blood samples of RK-33-treated SCID mice | |||
|---|---|---|---|
| DMSO ± SD | RK-33 ± SD | Normal range | |
| Blood cells | |||
| RBC (M/μl) | 10.48 ± 0.55 | 10.01 ± 0.77 | 6.36–9.42 |
| Hb (g/dl) | 15.2 ± 0.8 | 14.7 ± 0.6 | 11.0–15.1 |
| MCV (fl) | 52.2 ± 0.9 | 55.1 ± 1.3 | 45.4–60.3 |
| WBC (K/μl) | 4.14 ± 1.12 | 5.83 ± 2.61 | 1.8–10.7 |
| Thrombocytes (K/μl) | 1267 ± 196 | 746 ± 185 | 592–2,972 |
| Liver biochemical values | |||
| ALT (U/l) | 46 ± 8 | 72 ± 34 | 20–80 |
| AST (U/l) | 81 ± 3 | 224 ± 152 | 50–300 |
| ALP (U/l) | 82 ± 4 | 69 ± 5 | 28–96 |
| Kidney biochemical values | |||
| BUN (mg/dl) | 18 ± 1.0 | 22 ± 2.0 | 17–31 |
| Creatinine (mg/dl) | 0.30 ± 0.00 | 0.35 ± 0.05 | 0.3–1.0 |
| Calcium (mg/dl) | 9.2 ± 0.1 | 9.1 ± 0.2 | 9.0–13.0 |
| Albumin (g/dl) | 3.05 ± 0.25 | 3.05 ± 0.05 | 2.5–4.8 |
| Lipids and other biochemical values | |||
| Cholesterol (mg/dl) | 123 ± 10 | 120 ± 1 | 60–165 |
| Triglycerides (mg/dl) | 141 ± 38 | 215 ± 14 | 109–172 |
| Amylase (U/l) | 918 ± 13 | 905 ± 42 | 1,063–1,400 |
| Glucose (mg/dl) | 151 ± 5 | 166 ± 4 | 62–175 |
The table displays blood, liver, kidney, and lipid toxicity data from RK-33-treated SCID mice. RBC, red blood cells; Hb, hemoglobin; MCV, mean corpuscular volume; WBC, white blood cells; ALT, alanine aminotransferase; AST, aspartate transaminase; ALP, alkaline phosphatase; BUN, blood urea nitrogen.