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. 2015 Mar 23;7(5):670–687. doi: 10.15252/emmm.201404632

Figure 10.

Figure 10

Effects of oral administration of 2,4-dihydroxybenzoic acid (2,4-diHB) in Coq9+/+, Coq9Q95X and Coq9R239X mice and COQ9R244X patient fibroblasts
  1. A, B Kidney CoQ9 levels in Coq9+/+, Coq9Q95X and Coq9R239X mice treated with 2,4-diHB (+2,4-diHB) compared with the non-treated littermate (vehicle). Statistical analysis was performed on +2,4-diHB Coq9+/+, Coq9Q95X and Coq9R239X mice versus vehicle Coq9+/+, Coq9Q95X and Coq9R239X mice, respectively (n = 3 for each group).
  2. C, D CoQ10 levels in COQ9R244X skin fibroblasts treated with 2,4-DiHB (+2,4-diHB) compared with the non-treated controls (vehicle). Statistical analysis was performed on +2,4-diHB COQ9R244X versus vehicle COQ9R244X (n = 4 for each group).

Data information: Data are expressed as mean ± SD. Student' t-test. +P < 0.05; ++P < 0.01.