Fig 2. E₂ contributed to the sex differences in FC-induced autophagy and injury severity in the striatum.

All of the mice in every groups were infused with 3 μL of FC (1 mmol/L) into the right striatum. (A) E₂ reversed the increase of FC-induced LC3 lipidation by ovariectomy. (B) E₂ decreased the ratios of SBDP 145/150 to spectrin in both sterilized female (♀ with a slash) and male (♂ with a slash) mice after FC infusion. The data are expressed as the means ± SDs (n = 6), *p<0.05 compared with intact males; #p<0.05 compared with intact females; §p<0.05 compared with ovariectomized females.