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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Pharmacol Biochem Behav. 2015 Jun 1;135:97–104. doi: 10.1016/j.pbb.2015.05.019

Figure 5.

Figure 5

Effects of chronically infusing the GABA synthesis inhibitor L-allylglycine (LAG) into the medial prefrontal cortex on expression of GAD67, GAT1, parvalbumin (PV) and the NMDA NR1 subunit. A) Representative cannula placement. B) Schematic showing approximate locations of the tissue punches for the prelimbic (PrL) and infralimbic (IL) cortices (adapted from Paxinos and Watson, 2009). C-D) 6-Day exposure to LAG increased GAD67 expression in the prelimbic (PrL, C), but not infralimbic (IL, D) cortex. E-F) 13-Day exposure to LAG increased GAD67 expression in both the PrL (E) and IL (F). GAT1, PV and NR1 expression were not affected by chronic infusions of LAG. *P < 0.05, **P < 0.001 significantly different from VEH for that protein.