Table 3.
Between- and within-person associations of psychosocial and physiologic measures with fatigue intensity over 3 years
| Intensity |
|||||||
|---|---|---|---|---|---|---|---|
| Between- person |
Within- person |
||||||
| Predictor | Coefficient | 95% CI | P value |
Coefficient | 95% CI | P value |
|
| Psychosocial measures | |||||||
| Number of stressful events | 1.17 | (0.69, 1.65) | 0.000 | 0.14 | (0.03, 0.24) | 0.013 | |
| Davidson PTSD score | 1.19 | (0.82, 1.56) | 0.000 | 0.27 | (0.13, 0.42) | 0.000 | |
| HADS anxiety score | 1.63 | (1.34, 1.91) | 0.000 | 0.67 | (0.52, 0.82) | 0.000 | |
| Beck Depression Inventory score |
1.52 | (1.22, 1.82) | 0.000 | 0.66 | (0.50, 0.82) | 0.000 | |
| Social support | −0.54 | (−0.93, −0.15) | 0.007 | −0.11 | (−0.29, 0.06) | 0.213 | |
| Number of childhood traumas** |
0.34 | (0.14, 0.54) | 0.001 | ||||
| Number of adulthood traumas |
0.26 | (−0.07, 0.58) | 0.125 | ||||
| Number of all traumas | 0.27 | (0.10, 0.44) | 0.002 | ||||
| Physiologic measures | |||||||
| Aspartate aminotranspertase |
0.07 | (−0.36, 0.50) | 0.759 | −0.02 | (−0.18, 0.15) | 0.835 | |
| Alanine aminotraspertase | −0.05 | (−0.48, 0.37) | 0.802 | −0.06 | (−0.23, 0.11) | 0.478 | |
| Gamma glutamyl transpeptidase* |
−0.03 | (−0.41, 0.34) | 0.866 | 0.01 | (−0.26, 0.28) | 0.925 | |
| Alkaline phosphatase | 0.22 | (−0.20, 0.63) | 0.311 | 0.03 | (−0.14, 0.20) | 0.734 | |
| Total bilirubin | −0.10 | (−0.57, 0.36) | 0.661 | 0.00 | (−0.14, 0.14) | 0.978 | |
| TSH | −0.27 | (−0.66, 0.11) | 0.167 | −0.13 | (−0.31, 0.04) | 0.138 | |
| Thyroxine | 0.07 | (−0.37, 0.51) | 0.765 | 0.05 | (−0.09, 0.19) | 0.457 | |
| HIV RNA viral load* | 0.31 | (−0.14, 0.75) | 0.176 | 0.10 | (−0.04, 0.24) | 0.156 | |
| CD4 count | −0.28 | (−0.65, 0.08) | 0.128 | −0.12 | (−0.39, 0.14) | 0.370 | |
| CD4 percent | −0.33 | (−0.69, 0.03) | 0.073 | −0.27 | (−0.64, 0.10) | 0.153 | |
| CD8 | −0.36 | (−0.75, 0.03) | 0.072 | −0.11 | (−0.33, 0.11) | 0.319 | |
| T4/T8 ratio* | −0.27 | (−0.65, 0.11) | 0.158 | 0.02 | (−0.24, 0.28) | 0.874 | |
| CD16 count | −0.28 | (−0.73, 0.18) | 0.238 | 0.02 | (−0.12, 0.17) | 0.743 | |
| CD16 percent | −0.14 | (−0.61, 0.33) | 0.561 | 0.04 | (−0.10, 0.18) | 0.591 | |
| CD38 on CD8 | 0.08 | (−0.32, 0.49) | 0.685 | 0.06 | (−0.10, 0.23) | 0.470 | |
| Total testosterone | −0.35 | (−0.72, 0.01) | 0.056 | 0.20 | (−0.09, 0.49) | 0.179 | |
| Free testosterone | −0.56 | (−0.94, −0.18) | 0.004 | 0.09 | (−0.14, 0.33) | 0.442 | |
| DHEA | −0.44 | (−0.82, −0.06) | 0.024 | 0.11 | (−0.12, 0.35) | 0.341 | |
| Hemoglobin | −0.21 | (−0.57, 0.15) | 0.254 | −0.16 | (−0.37, 0.05) | 0.134 | |
| Hematocrit | −0.14 | (−0.51, 0.24) | 0.475 | −0.14 | (−0.34, 0.05) | 0.143 | |
| Serum erythropoietin* | −0.27 | (−0.68, 0.15) | 0.209 | 0.10 | (−0.11, 0.32) | 0.347 | |
| Lactic acid | −0.18 | (−0.66, 0.31) | 0.480 | 0.08 | (−0.07, 0.23) | 0.292 | |