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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: J Pain Symptom Manage. 2015 Feb 18;50(1):69–79. doi: 10.1016/j.jpainsymman.2015.02.006

Table 4.

Between- and within-person associations of psychosocial and physiologic measures with fatigue-related impact on functioning over 3 years

Impact on
functioning
Between-person
Within-person
Predictor Coefficient 95% CI P
value
Coefficient 95% CI P
value
Psychosocial measures
Number of stressful
events
1.15 (0.62, 1.67) 0.000 0.13 (0.02, 0.24) 0.022
Davidson PTSD score 1.31 (0.92, 1.70) 0.000 0.34 (0.19, 0.49) 0.000
HADS anxiety score 1.67 (1.34, 2.00) 0.000 0.68 (0.53, 0.84) 0.000
Beck Depression
Inventory score 1.68 (1.36, 2.00) 0.000 0.70 (0.53, 0.86) 0.000
Social support −0.65 (−1.07, −0.24) 0.002 −0.09 (−0.27, 0.09) 0.312
Number of childhood
traumas**
0.29 (0.08, 0.51) 0.008
Number of adulthood
traumas
0.34 (−0.01, 0.69) 0.054
Number of all traumas 0.26 (0.08, 0.44) 0.005
Physiologic measures
Aspartate
aminotranspertase
−0.06 (−0.51, 0.40) 0.813 −0.03 (−0.20, 0.14) 0.746
Alanine aminotraspertase −0.19 (−0.65, 0.27) 0.412 −0.09 (−0.26, 0.08) 0.294
Gamma glutamyl
transpeptidase*
−0.08 (−0.49, 0.32) 0.678 −0.02 (−0.30, 0.26) 0.883
Alkaline phosphatase 0.16 (−0.29, 0.60) 0.492 0.06 (−0.11, 0.24) 0.469
Total bilirubin 0.04 (−0.46, 0.54) 0.869 0.08 (−0.07, 0.22) 0.293
TSH −0.28 (−0.69, 0.14) 0.190 −0.09 (−0.27, 0.09) 0.324
Thyroxine 0.05 (−0.43, 0.52) 0.849 0.03 (−0.11, 0.18) 0.649
HIV RNA viral load* 0.33 (−0.14, 0.80) 0.171 0.02 (−0.13, 0.16) 0.803
CD4 count −0.14 (−0.54, 0.25) 0.477 −0.07 (−0.35, 0.20) 0.603
CD4 percent −0.23 (−0.62, 0.15) 0.239 −0.15 (−0.53, 0.23) 0.431
CD8 −0.36 (−0.77, 0.06) 0.093 −0.10 (−0.32, 0.12) 0.388
T4/T8 ratio* −0.21 (−0.61, 0.19) 0.305 −0.09 (−0.35, 0.18) 0.523
CD16 count −0.08 (−0.57, 0.41) 0.744 0.06 (−0.08, 0.21) 0.393
CD16 percent 0.02 (−0.48, 0.52) 0.928 0.05 (−0.09, 0.20) 0.449
CD38 on CD8 0.04 (−0.39, 0.48) 0.847 −0.04 (−0.21, 0.13) 0.673
Total testosterone −0.30 (−0.69, 0.09) 0.133 0.10 (−0.20, 0.39) 0.523
Free testosterone −0.43 (−0.84, −0.02) 0.042 0.03 (−0.21, 0.27) 0.787
DHEA −0.38 (−0.79, 0.04) 0.074 0.04 (−0.19, 0.28) 0.715
Hemoglobin −0.27 (−0.66, 0.12) 0.172 −0.16 (−0.37, 0.05) 0.145
Hematocrit −0.24 (−0.64, 0.16) 0.239 −0.15 (−0.34, 0.05) 0.153
Serum erythropoietin* −0.11 (−0.56, 0.33) 0.619 0.24 (0.02, 0.46) 0.033
Lactic acid −0.05 (−0.58, 0.48) 0.854 0.06 (−0.09, 0.21) 0.454