Table 4.
Between- and within-person associations of psychosocial and physiologic measures with fatigue-related impact on functioning over 3 years
| Impact on functioning |
|||||||
|---|---|---|---|---|---|---|---|
| Between-person |
Within-person |
||||||
| Predictor | Coefficient | 95% CI | P value |
Coefficient | 95% CI | P value |
|
| Psychosocial measures | |||||||
| Number of stressful events |
1.15 | (0.62, 1.67) | 0.000 | 0.13 | (0.02, 0.24) | 0.022 | |
| Davidson PTSD score | 1.31 | (0.92, 1.70) | 0.000 | 0.34 | (0.19, 0.49) | 0.000 | |
| HADS anxiety score | 1.67 | (1.34, 2.00) | 0.000 | 0.68 | (0.53, 0.84) | 0.000 | |
| Beck Depression | |||||||
| Inventory score | 1.68 | (1.36, 2.00) | 0.000 | 0.70 | (0.53, 0.86) | 0.000 | |
| Social support | −0.65 | (−1.07, −0.24) | 0.002 | −0.09 | (−0.27, 0.09) | 0.312 | |
| Number of childhood traumas** |
0.29 | (0.08, 0.51) | 0.008 | ||||
| Number of adulthood traumas |
0.34 | (−0.01, 0.69) | 0.054 | ||||
| Number of all traumas | 0.26 | (0.08, 0.44) | 0.005 | ||||
| Physiologic measures | |||||||
| Aspartate aminotranspertase |
−0.06 | (−0.51, 0.40) | 0.813 | −0.03 | (−0.20, 0.14) | 0.746 | |
| Alanine aminotraspertase | −0.19 | (−0.65, 0.27) | 0.412 | −0.09 | (−0.26, 0.08) | 0.294 | |
| Gamma glutamyl transpeptidase* |
−0.08 | (−0.49, 0.32) | 0.678 | −0.02 | (−0.30, 0.26) | 0.883 | |
| Alkaline phosphatase | 0.16 | (−0.29, 0.60) | 0.492 | 0.06 | (−0.11, 0.24) | 0.469 | |
| Total bilirubin | 0.04 | (−0.46, 0.54) | 0.869 | 0.08 | (−0.07, 0.22) | 0.293 | |
| TSH | −0.28 | (−0.69, 0.14) | 0.190 | −0.09 | (−0.27, 0.09) | 0.324 | |
| Thyroxine | 0.05 | (−0.43, 0.52) | 0.849 | 0.03 | (−0.11, 0.18) | 0.649 | |
| HIV RNA viral load* | 0.33 | (−0.14, 0.80) | 0.171 | 0.02 | (−0.13, 0.16) | 0.803 | |
| CD4 count | −0.14 | (−0.54, 0.25) | 0.477 | −0.07 | (−0.35, 0.20) | 0.603 | |
| CD4 percent | −0.23 | (−0.62, 0.15) | 0.239 | −0.15 | (−0.53, 0.23) | 0.431 | |
| CD8 | −0.36 | (−0.77, 0.06) | 0.093 | −0.10 | (−0.32, 0.12) | 0.388 | |
| T4/T8 ratio* | −0.21 | (−0.61, 0.19) | 0.305 | −0.09 | (−0.35, 0.18) | 0.523 | |
| CD16 count | −0.08 | (−0.57, 0.41) | 0.744 | 0.06 | (−0.08, 0.21) | 0.393 | |
| CD16 percent | 0.02 | (−0.48, 0.52) | 0.928 | 0.05 | (−0.09, 0.20) | 0.449 | |
| CD38 on CD8 | 0.04 | (−0.39, 0.48) | 0.847 | −0.04 | (−0.21, 0.13) | 0.673 | |
| Total testosterone | −0.30 | (−0.69, 0.09) | 0.133 | 0.10 | (−0.20, 0.39) | 0.523 | |
| Free testosterone | −0.43 | (−0.84, −0.02) | 0.042 | 0.03 | (−0.21, 0.27) | 0.787 | |
| DHEA | −0.38 | (−0.79, 0.04) | 0.074 | 0.04 | (−0.19, 0.28) | 0.715 | |
| Hemoglobin | −0.27 | (−0.66, 0.12) | 0.172 | −0.16 | (−0.37, 0.05) | 0.145 | |
| Hematocrit | −0.24 | (−0.64, 0.16) | 0.239 | −0.15 | (−0.34, 0.05) | 0.153 | |
| Serum erythropoietin* | −0.11 | (−0.56, 0.33) | 0.619 | 0.24 | (0.02, 0.46) | 0.033 | |
| Lactic acid | −0.05 | (−0.58, 0.48) | 0.854 | 0.06 | (−0.09, 0.21) | 0.454 | |