Table 2.

Single FAAH SNP associations with PONV and Respiratory Depression

outcome	SNP	location	white				black				Putative function
			minor allele (%)	p HWE	p association	OR (95% CI) Beta ± SE	minor allele (%)	p HWE	p association	OR (95% CI) Beta ± SE
PONV	rs4141964	46865040	A (0.39)	0.127	0.0014	2.42 (1.41, 4.16)	G (0.27)	0.472			intron
	rs3766246	46865671	T (0.39)	0.127	0.0014	2.42 (1.41, 4.16)	C (0.27)	0.134			intron
	rs324420	46870761	A (0.23)	0.008	0.0003	2.73 (1.58, 4.73)	A (0.41)	0.939			missense
	rs2295633	46874383	A (0.38)	0.103	0.0028	2.26 (1.32, 3.85)	G (0.43)	0.980			intron
	rs11576941	46875067	A (0.31)	0.867	0.0311	0.49 (0.26, 0.94)	A (0.10)	0.389			intron
	rs2295632	46879562	A (0.29)	0.029	0.0005	2.61 (1.52, 4.47)	C (0.35)	0.606			downstream
	kgp12517369	46882118	A (0.29)	0.029	0.0005	2.61 (1.52, 4.47)	G (0.42)	0.359			N/A
RD	rs4141964	46865040	A (0.39)	0.127	0.0402	1.57 (1.02, 2.41)	G (0.27)	0.472			intron
	rs3766246	46865671	T (0.39)	0.127	0.0402	1.57 (1.02, 2.41)	C (0.27)	0.134			intron
	rs324420	46870761	A (0.23)	0.008	0.0473	1.61 (1.01, 2.59)	A (0.41)	0.939			missense
	rs2295632	46879562	A (0.29)	0.029	0.0343	1.62 (1.04, 2.54)	C (0.35)	0.606			downstream
	kgp12517369	46882118	A (0.29)	0.029	0.0343	1.62 (1.04, 2.54)	G (0.42)	0.359			N/A

Note: effects were shown as odds ratio (OR) and 95% CI for Postoperative Nausea and Vomiting (PONV) and respiratory depression (RD). OR indicated the odds ratio when minor allele increased by one copy; effect for total morphine was shown as dose increase for one copy increase of the minor allele.

In white children, tests on genetic association with PONV were adjusted for sex and total morphine dose; tests on genetic association with RD were adjusted for total morphine dose and BMI z score. In black children, no statistically significant co-variables were detected; therefore no co-variables were included in the genetic association tests.