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. 2015 Jul 6;10(7):e0132336. doi: 10.1371/journal.pone.0132336

Fig 5. Therapeutic treatment with anti-TLR2 and anti-TLR4 improve sepsis.

Fig 5

Mice were treated with individual anti-TLR2 or anti-TLR4 antibodies 3 hours after the CLP procedure. Treatment with both antibodies in combination decreased the number of bacteria in the peritoneum (A) and serum (B) as well as the levels of TNF-α in the peritoneum (C) and serum (D) 6 hours after sepsis compared to the negative control isotype IgG antibody treatment (CLP). * p<0.05 between CLP and Sham groups. # p<0.05 between the antibody treatment and negative control isotype IgG treated-group. Horizontal bars in Fig 5A/5B represent median value. Antibody dose (1 mg/animal). Used 6 animals/group, except isotype IgG antibody treated group (n = 10). Missing points in Figs reflect number of bacteria below detection limit.