Table 4. Logistic regression analyses on associations between single nucleotide polymorphism rs7248320 (A>G) genotypes and risk of hepatocellular carcinoma and cervical cancer.
| Genotype | Hepatocellular carcinoma | Cervical cancer | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients (N = 1300) n (%) | Controls (N = 1344) n (%) | OR(95%CI) | P | OR(95%CI) a | P a | Patients (N = 1486) n (%) | Controls (N = 1536) n (%) | OR(95%CI) | P | OR(95%CI) b | P b | |
| rs7248320 | ||||||||||||
| AA | 524(41.3%) | 564(42.4%) | 1 | 1 | 535(39.5%) | 614(42.3%) | 1 | 1 | ||||
| GA | 540(42.5%) | 600(45.1%) | 0.97(0.82–1.14) | 0.708 | 0.97(0.82–1.15) | 0.755 | 587(43.4%) | 640(44.1%) | 1.03(0.88–1.20) | 0.706 | 1.05(0.89–1.24) | 0.519 |
| GG | 206(16.2%) | 167(12.5%) | 1.33(1.05–1.68) | 0.019 | 1.27(1.00–1.61) | 0.053 | 231(17.1%) | 196(13.5%) | 1.37(1.10–1.70) | 0.005 | 1.38(1.10–1.73) | 0.005 |
| GG vs. AA/GA | 1.35(1.08–1.68) | 0.008 | 1.28(1.03–1.61) | 0.028 | 1.35(1.10–1.65) | 0.004 | 1.34(1.09–1.66) | 0.006 | ||||
CI, confidence interval; OR, odds ratio. The boldface values represent these P values were less than 0.05.
aAdjusted for age, gender, smoking status and drinking status.
bAdjusted for age, smoking status, menopausal status, family history of any cancer and parity.