Table 6. Stratified analyses on association between rs7248320 genotypes and cervical cancer risk.
| Variables | Patients/ Controls N (%) | OR(95%CI) a | P b | |
|---|---|---|---|---|
| AA/GA | GG | |||
| Age | 0.118 | |||
| ≤53 | 554(79.5)/679(85.3) | 143(20.5)/117(14.7) | 1.59(1.21–2.10) | |
| >53 | 567(86.6)/575(87.9) | 88(13.4)/79(12.1) | 1.13(0.81–1.56) | |
| Smoking status | 0.498 | |||
| Ever | 45(86.5)/20(90.9) | 7(13.5)/2(9.1) | 2.49(0.42–14.79) | |
| Never | 1076(82.8)/1234(86.4) | 224(17.2)/194(13.6) | 1.34(1.09–1.66) | |
| Menopausal status | 0.014 | |||
| Premenopausal | 470(78.9)/508(86.5) | 126(21.1)/79(13.5) | 1.82(1.33–2.48) | |
| Menopause | 651(86.1)/746(86.4) | 105(13.9)/117(13.6) | 1.07(0.80–1.42) | |
| Family history of any cancer | 0.830 | |||
| Yes | 210(82.7)/256(86.2) | 44(17.3)/41(13.8) | 1.41(0.87–2.28) | |
| No | 911(83.0)/998(86.6) | 187(17.0)/155(13.4) | 1.33(1.06–1.68) | |
| Parity | 0.305 | |||
| 0–1 | 455(80.2)/612(86.3) | 112(19.8)/97(13.7) | 1.6(1.19–2.16) | |
| 2 | 319(83.5)/336(85.1) | 63(16.5)/59(14.9) | 1.09(0.73–1.62) | |
| >2 | 347(86.1)/306(88.4) | 56(13.9)/40(11.6) | 1.29(0.83–2.00) | |
aAdjusted for age, smoking status, menopausal status, family history of any cancer and parity (excluded the stratified factor in each stratum).
b P-value for the heterogeneity test.